HTTP 404.4 on IIS 7 Running Plesk

Hi,

I receive an HTTP 404.4 error on IIS 7 that's running Plesk.  The StaticFile HTTP Handler is created in the top level of IIS.  The site is set to run in a ASP.NET 4.0 Classic application pool.  Can anyone help me with a fix to this issue?  Does the StaticFile HTTP Handler need to be added to the DotNetNuke web.config?  Should we switch to an Integrated Application Pool?

Thanks,

Sdi